Featured Top 25 match-ups this week include (11) Mississippi State at (1) Alabama, (10) Georgia at (2) Florida, (14) Texas Tech at (3) Kansas State, and (5) Notre Dame at (8) Oklahoma.
Other top games include (9) USC at Arizona, Duke at (12) Florida State, Cincinnati at (16) Louisville, Kent State at (15) Rutgers, and (22) Michigan at Nebraska.
ESPN Gameday will broadcast live from Norman, the site of Notre Dame at Oklahoma game.
Listed below are the games with TV, time and network. The schedule is also optimized for printing:
| Thursday, Oct. 25, 2012 | |||
| Game | Time (ET) | Network | Online |
| Clemson at Wake Forest | 7:30 p.m. | ESPN (HD) | ESPN3 |
| Friday, Oct. 26, 2012 | |||
| Cincinnati at Louisville | 8:00 p.m. | ESPN (HD) | ESPN3 |
| Nevada at Air Force | 8:00 p.m. | CBSSN (HD) | — |
| Saturday, Oct. 27, 2012 | |||
| Ball State at Army | 12:00 p.m. | CBSSN (HD) | — |
| Indiana at Illinois | 12:00 p.m. | BTN (HD) | BTN2Go |
| Iowa at Northwestern | 12:00 p.m. | ESPN2 (HD) | ESPN3 |
| Kentucky at Missouri | 12:00 p.m. | ESPNU (HD) | ESPN3 |
| N. Illinois at W. Michigan | 12:00 p.m. | ERTV/ESPN-GP | ESPN3 |
| Temple at Pittsburgh | 12:00 p.m. | SNY/MASN/CSCA/ESPN-GP | ESPN3 |
| Texas at Kansas | 12:00 p.m. | FSN (HD)/FCSC | — |
| Tennessee at South Carolina | 12:00 p.m. | ESPN (HD)/ESPN3D | ESPN3 |
| Ole Miss at Arkansas | 12:21 p.m. | SEC Network (HD)/ ESPN-GP | ESPN3 |
| NC State at North Carolina | 12:30 p.m. | ACC Network (HD)/ESPN-GP | — |
| Maryland at Boston College | 1:00 p.m. | — | ESPN3 |
| Southern Miss at Rice | 1:00 p.m. | CSNC/CSBA/CSS | — |
| Utah State at UTSA | 2:00 p.m. | — | ESPN3 |
| BYU at Georgia Tech | 3:00 p.m. | FSN (HD)/ESPN-GP | ESPN3 |
| Colorado at Oregon | 3:00 p.m. | Pac-12 Network (HD) | Pac-12 |
| Memphis at SMU | 3:00 p.m. | TW Texas | Video |
| UCLA at Arizona State | 3:00 p.m. | FX (HD) | — |
| Akron at Central Michigan | 3:30 p.m. | — | Video |
| Boise State at Wyoming | 3:30 p.m. | CBSSN (HD) | — |
| Duke at Florida State | 3:30 p.m. | ESPNU (HD) | — |
| E. Michigan at Bowling Green | 3:30 p.m. | BCSN/ESPN-GP | ESPN3 |
| Florida vs. Georgia | 3:30 p.m. | CBS (HD) | CBS |
| Fresno State at New Mexico | 3:30 p.m. | CSCA/TWCS | — |
| Kent State at Rutgers | 3:30 p.m. | SNY/MASN/ERTV/ESPN-GP | ESPN3 |
| Michigan State at Wisconsin | 3:30 p.m. | ABC or ESPN2 (HD) | — |
| Navy at East Carolina | 3:30 p.m. | FCS | — |
| North Texas at Middle Tennessee | 3:30 p.m. | — | ESPN3 |
| Ohio at Miami Ohio | 3:30 p.m. | STO/ERTV/ESPN-GP | ESPN3 |
| Purdue at Minnesota | 3:30 p.m. | BTN (HD) | BTN2Go |
| TCU at Oklahoma State | 3:30 p.m. | FSN (HD) | — |
| Texas Tech at Kansas State | 3:30 p.m. | FOX (HD) | — |
| Toledo at Buffalo | 3:30 p.m. | TWCSN | — |
| UAB at Tulane | 3:30 p.m. | — | Video |
| USC at Arizona | 3:30 p.m. | ABC or ESPN2 (HD) | — |
| Texas State at San Jose State | 4:00 p.m. | TBA | Video |
| UTEP at Houston | 4:30 p.m. | CSS | — |
| Ohio State at Penn State | 5:30 p.m. | ESPN (HD) | ESPN3 |
| Western Kentucky at FIU | 6:00 p.m. | — | ESPN3 |
| Washington State at Stanford | 6:15 p.m. | Pac-12 Network (HD) | Pac-12 |
| Baylor at Iowa State | 7:00 p.m. | FSN (HD) | — |
| Hawaii at Colorado State | 7:00 p.m. | RSRM/KTVD | — |
| South Alabama at ULM | 7:00 p.m. | Cox 4 | ESPN3 |
| Syracuse at South Florida | 7:00 p.m. | — | ESPN3 |
| Texas A&M at Auburn | 7:00 p.m. | ESPNU (HD) | — |
| UMass at Vanderbilt | 7:00 p.m. | FS South (HD)/ESPN-GP | ESPN3 |
| La. Tech at New Mexico State | 8:00 p.m. | CSN Houston/ESPN-GP | ESPN3 |
| Michigan at Nebraska | 8:00 p.m. | ESPN2 (HD) | — |
| Notre Dame at Oklahoma | 8:00 p.m. | ABC (HD) | — |
| UCF at Marshall | 8:00 p.m. | CBSSN (HD) | — |
| UNLV at San Diego State | 8:00 p.m. | TWCSN | — |
| Mississippi State at Alabama | 8:30 p.m. | ESPN (HD) | — |
| California at Utah | 9:45 p.m. | Pac-12 Network (HD) | Pac-12 |
| Oregon State at Washington | 10:15 p.m. | Pac-12 Network (HD) | Pac-12 |