Featured Top 25 match-ups this week include (1) Alabama at Missouri, (3) South Carolina at (9) LSU, (15) Texas vs. (13) Oklahoma, and (22) Texas A&M vs. (23) Louisiana Tech.
Other top games include (4) Florida at Vanderbilt, (5) West Virginia at Texas Tech, (6) Kansas State at Iowa State, (10) Oregon State at BYU, and (11) USC at Washington.
ESPN Gameday will broadcast live from South Bend, Indiana, the site of the 17th-ranked Stanford at 7th-ranked Notre Dame game.
Listed below are the games with TV, time and network. The schedule is also optimized for printing:
| Thursday, Oct. 11, 2012 | |||
| Game | Time (ET) | Network | Online |
| Western Kentucky at Troy | 7:30 p.m. | ESPNU (HD) | ESPN3 |
| UTEP at Tulsa | 8:00 p.m. | FSN (HD)/FCSC | — |
| Arizona State at Colorado | 9:00 p.m. | ESPN (HD) | — |
| Friday, Oct. 12, 2012 | |||
| Navy at Central Michigan | 8:00 p.m. | ESPN2 (HD) | ESPN3 |
| Saturday, Oct. 13, 2012 | |||
| Louisville at Pittsburgh | 11:00 a.m. | ESPNU (HD) | — |
| Iowa at Michigan State | 12:00 p.m. | ESPN (HD) (3D) | ESPN3 |
| Kansas State at Iowa State | 12:00 p.m. | FX (HD) | — |
| Kent State at Army | 12:00 p.m. | CBSSN (HD) | — |
| Northwestern at Minnesota | 12:00 p.m. | ESPN2 (HD) | ESPN3 |
| Oklahoma vs. Texas (Dallas) | 12:00 p.m. | ABC (HD) | — |
| Syracuse at Rutgers | 12:00 p.m. | SNY/MASN/CSCA/ESPN-GP | ESPN3 |
| UAB at Houston | 12:00 p.m. | FSN (HD)/FCSC | — |
| Wisconsin at Purdue | 12:00 p.m. | BTN (HD) | — |
| Auburn at Ole Miss | 12:21 p.m. | SEC Network (HD)/ESPN-GP | ESPN3 |
| Duke at Virginia Tech | 12:30 p.m. | ACC Network (HD)/ESPN-GP | ESPN3 |
| SMU at Tulane | 1:00 p.m. | CSS | — |
| Temple at Connecticut | 1:00 p.m. | — | ESPN3 |
| Toledo at Eastern Michigan | 1:00 p.m. | — | Video |
| Akron at Ohio | 2:00 p.m. | — | ESPN3 |
| North Carolina at Miami | 2:30 p.m. | ESPNU (HD) | ESPN3 |
| Maryland at Virginia | 3:00 p.m. | FSN (HD)/ESPN-GP | — |
| Nevada at UNLV | 3:00 p.m. | TW/Charter/Cox (NV) | ESPN3 |
| Utah at UCLA | 3:00 p.m. | FOX (HD) | — |
| Western Michigan at Ball State | 3:00 p.m. | — | ESPN3 |
| Alabama at Missouri | 3:30 p.m. | CBS (HD) | CBS |
| Buffalo at Northern Illinois | 3:30 p.m. | CSNC/ESPN-GP | — |
| Fresno State at Boise State | 3:30 p.m. | NBCSN (HD) | — |
| Illinois at Michigan | 3:30 p.m. | ABC or ESPN (HD) | — |
| Miami (OH) at Bowling Green | 3:30 p.m. | BCSN | ESPN3 |
| Oklahoma State at Kansas | 3:30 p.m. | FSN (HD)/FCSC | — |
| Oregon State at BYU | 3:30 p.m. | ABC (HD)/ESPN-GP | ESPN3 |
| Stanford at Notre Dame | 3:30 p.m. | NBC (HD) | NBC |
| UTSA at Rice | 3:30 p.m. | FCS | — |
| West Virginia at Texas Tech | 3:30 p.m. | ABC or ESPN (HD)/ESPN-GP | ESPN3 |
| Utah State at San Jose State | 4:00 p.m. | ALT/MASN/CSBA/ESPN-GP | ESPN3 |
| Memphis at East Carolina | 4:30 p.m. | CSS | — |
| Boston College at Florida State | 5:30 p.m. | ESPN2 (HD) | — |
| Florida at Vanderbilt | 6:00 p.m. | ESPNU (HD) | — |
| Colorado State at San Diego State | 6:30 p.m. | KTVD/TW | — |
| Air Force at Wyoming | 7:00 p.m. | RSRM | — |
| Fordham at Cincinnati | 7:00 p.m. | — | ESPN3 |
| Idaho at Texas State | 7:00 p.m. | ALT (HD)/ESPN-GP | — |
| Kentucky at Arkansas | 7:00 p.m. | FS South (HD)/ESPN-GP | — |
| TCU at Baylor | 7:00 p.m. | FSN (HD)/FCSC | — |
| USC at Washington | 7:00 p.m. | FOX (HD) | — |
| Florida Atlantic at ULM | 8:00 p.m. | Sun Belt Network/ESPN-GP | ESPN3 |
| Ohio State at Indiana | 8:00 p.m. | BTN (HD) | BTN2Go |
| South Carolina at LSU | 8:00 p.m. | ESPN (HD) | — |
| Southern Miss at UCF | 8:00 p.m. | CBSSN (HD) | — |
| Tennessee at Mississippi State | 9:00 p.m. | ESPN2 (HD) | — |
| Texas A&M vs. La. Tech (Shreveport) | 9:15 p.m. | ESPNU (HD) | — |
| California at Washington State | 10:30 p.m. | PAC-12 Network (HD) | Pac-12 |
| New Mexico at Hawaii | 12:00 a.m. | ROOT/Oceanic PPV | — |